RESUMO
Canine distemper virus (CDV) has recently emerged as an extinction threat for the endangered Amur tiger (Panthera tigris altaica). CDV is vaccine-preventable, and control strategies could require vaccination of domestic dogs and/or wildlife populations. However, vaccination of endangered wildlife remains controversial, which has led to a focus on interventions in domestic dogs, often assumed to be the source of infection. Effective decision making requires an understanding of the true reservoir dynamics, which poses substantial challenges in remote areas with diverse host communities. We carried out serological, demographic, and phylogenetic studies of dog and wildlife populations in the Russian Far East to show that a number of wildlife species are more important than dogs, both in maintaining CDV and as sources of infection for tigers. Critically, therefore, because CDV circulates among multiple wildlife sources, dog vaccination alone would not be effective at protecting tigers. We show, however, that low-coverage vaccination of tigers themselves is feasible and would produce substantive reductions in extinction risks. Vaccination of endangered wildlife provides a valuable component of conservation strategies for endangered species.
Assuntos
Cinomose/prevenção & controle , Espécies em Perigo de Extinção/economia , Tigres/virologia , Vacinação/economia , Vacinas Virais/administração & dosagem , Animais , Animais Selvagens/virologia , Tomada de Decisões Gerenciais , Reservatórios de Doenças/veterinária , Reservatórios de Doenças/virologia , Cinomose/epidemiologia , Cinomose/transmissão , Cinomose/virologia , Vírus da Cinomose Canina/genética , Vírus da Cinomose Canina/imunologia , Cães/sangue , Cães/virologia , Estudos de Viabilidade , Feminino , Masculino , Modelos Econômicos , Filogenia , Estudos Soroepidemiológicos , Sibéria , Tigres/sangue , Vacinação/métodos , Cobertura Vacinal/economia , Cobertura Vacinal/métodos , Cobertura Vacinal/organização & administração , Vacinas Virais/economiaRESUMO
The critically endangered population of Far Eastern leopards ( Panthera pardus orientalis) may number as few as 60 individuals and is at risk from stochastic processes such as infectious disease. During May 2015, a case of canine distemper virus (CDV) was diagnosed in a wild leopard exhibiting severe neurologic disease in the Russian territory of Primorskii Krai. Amplified sequences of the CDV hemagglutinin gene and phosphoprotein gene aligned within the Arctic-like clade of CDV, which includes viruses from elsewhere in Russia, China, Europe, and North America. Histologic examination of cerebral tissue revealed perivascular lymphoid cuffing and demyelination of the white matter consistent with CDV infection. Neutralizing antibodies against CDV were detected in archived serum from two wild Far Eastern leopards sampled during 1993-94, confirming previous exposure in the population. This leopard population is likely too small to maintain circulation of CDV, suggesting that infections arise from spillover from more-abundant domestic or wild carnivore reservoirs. Increasing the population size and establishment of additional populations of leopards would be important steps toward securing the future of this subspecies and reducing the risk posed by future outbreaks of CDV or other infectious diseases.
